GSK143 dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12736A |
| CAS # | 2341796-81-2 |
| Pricing | inquire |
| Biological Activity | GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC50=7.1)[1]. GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice[2][3]. |
| MWt | 415.32 |
| Formula | C₁₇H₂₄Cl₂N₆O₂ |