Tomivosertib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-100022-10 mg |
| CAS # | 1849590-01-7 |
| Pricing | 10 mg, USD $310.0 |
| Synonyms | eFT508 |
| MWt | 340.38 |
| Formula | C₁₇H₂₀N₆O₂ |
| Biological Activity | Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance[2]. |
| Purity | 99.92% |