D-alpha-Hydroxyglutaric acid-[13C5] disodium salt
D-alpha-Hydroxyglutaric acid-[13C5] disodium salt is the labelled analogue of Disodium (R)-2-Hydroxyglutarate. Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-000531 |
| Pricing | Inquire |
| Cas | 1648909-80-1 |
| Molecular Weight | 197.04 |
| Molecular Formula | [13C]5H6Na2O5 |
| Canonical SMILES | C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+] |