PF 477736
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-10032-50 mg |
| CAS # | 952021-60-2 |
| Pricing | 50 mg, USD $552.0 |
| Synonyms | PF 00477736 |
| MWt | 419.48 |
| Formula | C₂₂H₂₅N₇O₂ |
| Biological Activity | PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2]. |
| Purity | 99.21% |