KRAS inhibitor-9

Supplier MedChemExpress
Product # HY-137497-10 mg
CAS # 300809-71-6
Pricing 10 mg, USD $250.0
Biological Activity KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
Purity 99.98%
MWt 292.81
Formula C₁₃H₉ClN₂S₂
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