SB 203580
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-10256-50 mg |
| CAS # | 152121-47-6 |
| Pricing | 50 mg, USD $96.0 |
| Synonyms | RWJ 64809 |
| MWt | 377.43 |
| Formula | C₂₁H₁₆FN₃OS |
| Biological Activity | SB 203580 (RWJ 64809) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. SB 203580 does not disrupt JNK activity and is an autophagy and mitophagy activator[1]. |
| Purity | 99.92% |