TED-347
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-125269-5 mg |
| CAS # | 2378626-29-8 |
| Pricing | 5 mg, USD $130.0 |
| Biological Activity | TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1]. |
| Purity | 98.78% |
| MWt | 313.7 |
| Formula | C₁₅H₁₁ClF₃NO |