SP600125 (Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone, Anthrapyrazolone, JNK Inhibitor II, SAPK Inhibitor II, CAS 129-56-6), >98%

LC Laboratories' Product Number S-7979 - SP600125 (Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone, Anthrapyrazolone, JNK Inhibitor II, SAPK Inhibitor II), >99% - for research use only. Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures. In animal studies, SP600125 inhibited bacterial lipopolysaccharide-induced expression of tumor necrosis factor-α and prevented anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes. SP600125 completely inhibited IL-1-induced accumulation of phospho-Jun and initiation of c-Jun transcription in synoviocytes. SP600125 inhibited JNK, reduced the levels of c-Jun phosphorylation, prevented apoptosis in dopaminergic neurons, and partly reversed the loss of dopamine in MPTP-induced Parkinson's disease in C57BL/6N mice.

• Supplier: LC Laboratories
• Product #: S-7979
• Sku #: S-7979_1g