Darusentan
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15404-5 mg |
| CAS # | 171714-84-4 |
| Pricing | 5 mg, USD $130.0 |
| Synonyms | Lu-135252 |
| MWt | 410.42 |
| Formula | C₂₂H₂₂N₂O₆ |
| Biological Activity | Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors[1]. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM[2]. |
| Purity | 98.66% |