Pexidartinib hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-16749A-500 mg |
| CAS # | 2040295-03-0 |
| Pricing | 500 mg, USD $450.0 |
| Synonyms | PLX-3397 hydrochloride |
| MWt | 454.28 |
| Formula | C₂₀H₁₆Cl₂F₃N₅ |
| Biological Activity | Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity[1]. |
| Purity | 99.95% |