Tazemetostat
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13803-200 mg |
| CAS # | 1403254-99-8 |
| Pricing | 200 mg, USD $290.0 |
| Synonyms | EPZ-6438; E-7438 |
| MWt | 572.74 |
| Formula | C₃₄H₄₄N₄O₄ |
| Biological Activity | Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat (EPZ-6438) inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat (EPZ-6438) inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat (EPZ-6438) inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat (EPZ-6438) also inhibits EZH1 with an IC50 of 392 nM[1]. |
| Purity | ≥98.0% |