Anti-MSLN immunotoxin RG7787 (Fab)-PE
This immunotoxin was achieved by conjugating/fusing the Anti-MSLN Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells expressed the cells surface antigen MSLN. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating pancreatic cancer.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G052E |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | MSLN |
| Species Reactivity | Human |