Tazemetostat (EPZ-6438)
Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7128 |
| Sku # | S7128-50mg |
| Pricing | 50mg, $670.00 |
Citations for this product:
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bioRxiv - Systems Biology 2022Quote: ... 10μM tazemetostat (Selleck Chemicals #S7128), 10μM TMP269 (Selleck Chemicals #S7324) ...
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bioRxiv - Cancer Biology 2023Quote: Tazemetostat (TAZ or EPZ6438, Selleck Chemicals S7128 and Cayman Chemical 16174), CPI- 1205 (Selleck Chemicals S8353 ...
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bioRxiv - Genetics 2023Quote: ... cells were treated with Tazemetostat (S7128, Selleck Chemicals), Chaetocin (13156 ...
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bioRxiv - Cancer Biology 2023Quote: Cells were treated with 1μM or 5μM of PRC2 inhibitors (EPZ6438 (Selleck Chemicals, # S7128) and GSK343 (Sigma-Aldrich ...