Tubastatin A, Hydrochloride Salt (CAS 1310693-92-5), 99%

LC Laboratories' Product Number T-5335 - Tubastatin A, Hydrochloride Salt (CAS 1310693-92-5), 99% - for research use only. Tubastatin A is a histone deacetylase (HDAC) 6 inhibitor. It inhibited HDAC6 with an IC50 of 15 nM, also inhibited HDAC1 (IC50 = 16.4 µM) and HDAC8 (IC50 = 0.85 µM), but not other HDACs (IC50 > 30 µM). It induced the acetylation of α-tubulin and protected primary cortical neurons against glutathione depletion-induced oxidative stress. Tubastatin A restored the expression of primary cilia in cholangiocarcinoma cell lines, decreased cell proliferation, and inhibited anchorage-independent growth. These effects of tubastatin A were blocked by stable transfection of IFT88-shRNA, which prevented cholangiocarcinoma cells from regenerating cilia. Tubastatin A also inhibited the tumor growth in a cholangiocarcinoma animal model. HDAC6 inhibition either by HDAC6 knockout or with tubastatin A promoted Foxp3(+) T-regulatory cell inhibitory activity in models of inflammation and autoimmunity. It blocked the development and progression of murine colitis and prevented allograft rejection in mice. Related CAS numbers: 1239262-52-2 for the trifluoroacetate salt; 1252003-15-8 for the free base.

• Supplier: LC Laboratories
• Product #: T-5335
• Sku #: T-5335_25mg