APS-2-79 HCl
APS-2-79 is a MAPK antagonist which can modulate KSR-dependent MAPK signalling by antagonizing RAF heterodimerization and the conformational changes required for phosphorylation and activation of KSR-bound MEK. APS-2-79 was found to bind to the KSR active site with an IC50 value of 120 nM, antagonizing MEK (MAPKK) phosphorylation by RAF.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2002381-31-7 |
| Pricing | Inquire |
| Cas | 2002381-31-7 |
| Molecular Weight | 423.89 |
| Molecular Formula | C23H21N3O3.HCl |
| Canonical SMILES | CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl |