MGS-0039
MGS-0039, also known as BCI-632, is a group II metabotropic glutamate receptor (mgluR2/3) antagonist potentially for the treatment of cognitive disorders, depression and anxiety. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD266 |
| CAS # | 569686-87-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | MGS-0039; MGS 0039; MGS0039; BCI-632; BCI632; BCI 632 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C15H14Cl2FNO5 |
| Exact Mass | 377.0233 |
| Molecular Weight | 378.1774 |
| Elemental Analysis | C, 47.64; H, 3.73; Cl, 18.75; F, 5.02; N, 3.70; O, 21.15 |
| IUPAC/Chemical Name | (1R,2R,3R,5R,6R)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
| InChi Key | LFAGGDAZZKUVKO-JAGWWQSPSA-N |
| InChi Code | InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1 |
| SMILES Code | O=C([C@@]1(N)[C@]2([H])[C@](C(O)=O)(F)[C@]2([H])C[C@H]1OCC3=CC=C(Cl)C(Cl)=C3)O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |