Lenalidomide-C4-NH2 hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-115446A-500 mg |
| Pricing | 500 mg, USD $1450.0 |
| Synonyms | Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride |
| MWt | 351.83 |
| Formula | C₁₇H₂₂ClN₃O₃ |
| Biological Activity | Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1]. |
| Purity | 98.24% |