Anti-CD4 immunotoxin M-T151 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-CD4 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute lymphoblastic leukemias (ALL).
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G078R |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | CD4 |
| Species Reactivity | Human |