GNF179 Metabolite
GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1310455-86-7 |
| Pricing | Inquire |
| Cas | 1310455-86-7 |
| Molecular Weight | 245.3 |
| Molecular Formula | C14H16FN3 |
| Canonical SMILES | CC1(C2=NC(=CN2CCN1)C3=CC=C(C=C3)F)C |