Trametinib (GSK1120212)
Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S2673 |
| Sku # | S2673-10mM/1mL |
| Pricing | 10mM/1mL, $97.00 |
Citations for this product:
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bioRxiv - Systems Biology 2021Quote: ... 100 μM trametinib (Selleck Chemicals, S2673), and 4mM paclitaxel (Life Technologies ...
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bioRxiv - Molecular Biology 2022Quote: ... Trametinib (S2673) and BPTES (5301) were purchased from Selleck Chemicals and Tocris Bioscience ...
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bioRxiv - Molecular Biology 2022Quote: ... trametinib (S2673) are from Selleck Chemicals and Proteasome inhibitor I from Calbiochem (539160 ...
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bioRxiv - Cancer Biology 2019Quote: ... at 0 to 10 μM and/or trametinib (Selleck Chemicals, #S2673) at 0.01 μM ...
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bioRxiv - Cancer Biology 2022Quote: ... Trametinib (S2673) and palbociclib (S1116) were purchased from Selleck Chemicals. The following antibodies were used for Western blot analysis or staining in this study ...
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bioRxiv - Physiology 2022Quote: ... ISO (10uM) and OXT+ISO with or without Trametinib (Selleck Chemicals, S2673; 5nM) were added to the media ...
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bioRxiv - Cancer Biology 2023Quote: Trametinib (S2673) and palbociclib (S1116) were purchased from Selleck Chemicals and MedChemExpress ...