Anti-Itgae immunotoxin M290 (IgG)-Sap
This immunotoxin was achieved by conjugating/fusing the Anti-Itgae monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Itgae-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of organ allograft rejection and graft-versus-host disease.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G046S |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Rat |
| Target | Itgae |
| Species Reactivity | Mouse |