Nintedanib, Ethanesulfonate Salt (BIBF1120 Esylate, Intedanib Esylate, Nintedanib Esylate, Vargatef, CAS 656247-18-6), >99%

LC Laboratories' Product Number N-9055 - Nintedanib, Ethanesulfonate Salt (BIBF1120 Esylate, Intedanib Esylate, Nintedanib Esylate, Vargatef, 656247-18-6), >99% - for research use only. Nintedanib (BIBF1120, Intedanib, Vargatef) is an indolinone derivative that potently inhibits vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) kinase activity in enzymatic assays (table 1). It blocks mitogen-activated protein kinase and Akt signaling pathways in three cell types contributing to angiogenesis, namely endothelial cells, pericytes, and smooth muscle cells, and it inhibits cell proliferation with an EC50 of 10-80 nM. Nintedanib significantly decreased blood vessel area and inhibited tumour growth. A reproducible hepatic perfusion index (HPI) was determined by using quantified gadopentetate dimeglumine (Gd-DTPA) concentration. The HPI decreased significantly at 28 days after treatment with nintedanib. HPI may be useful for monitoring antiangiogenic treatment response of hepatic metastases. This research compound is the ethanesulfonate salt form of nintedanib; please see the other form of this product, Nintedanib, Free Base, Cat. No. N-9077, for further technical information about both of these research compounds. This nintedanib product is the ethanesulfonate salt, whose CAS number is given above. The CAS number of the Nintedanib, Free Base form is 656247-17-5. Nintedanib is the active ingredient in the drug formulation designated by the trade name Vargatef®. This drug has been used in human clinical trials for patients with non-small cell lung, colorectal, uterine, endometrial, ovarian, and cervical cancer and multiple myeloma. NOTE: THE NINTEDANIB, ETHANESULFONATE SALT RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT VARGATEF®, AND IS NOT FOR HUMAN USE.

• Supplier: LC Laboratories
• Product #: N-9055
• Sku #: N-9055_5g