Rigosertib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12037A-50 mg |
| CAS # | 592542-59-1 |
| Pricing | 50 mg, USD $540.0 |
| Synonyms | ON-01910 |
| MWt | 451.49 |
| Formula | C₂₁H₂₅NO₈S |
| Biological Activity | Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3]. |
| Purity | 98.81% |