Human Anti-HIV-1 gp120 Recombinant Antibody (clone MAb 2158)
This is a anti-gp120 monoclonal antibody (MAb) 2158, which targets a conformational V2 epitope overlapping the 47 integrin binding site, and constructed a full-length model of V1V2. MAb 2158 was isolated from a subtype B virusinfected subject and is broadly cross-reactive and capable of neutralizing many tier 1 viruses. However, it does not neutralize tier 2 viruses, even though it can bind quite a few tier 2 gp120s; an increased length of V2 and increased total number of glycosylation sites within the hypervariable region are possibilities for the discordance between 2158 binding and neutralization.
Supplier | Creative Biolabs |
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Product # | HPAB-S0052-YC |
Pricing | Inquiry |
Host | Human |
Target | HIV-1 gp120 |
Species Reactivity | HIV-1 |
Type | Human IgG |
Applications | ELISA, Neut |
Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |