JH-XI-10-02
JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2209085-22-1 |
| Pricing | Inquire |
| Cas | 2209085-22-1 |
| Molecular Weight | 920.14 |
| Molecular Formula | C53H69N5O9 |
| Canonical SMILES | O=C1C=2C=CC=C(NCCOCCOCCOCCOCCC(=O)N(C)C3CCC4(C)C(CCC5C6CCC(C=7C=CC=8C=CN=CC8C7)C6(C)CCC54)C3)C2C(=O)N1C9C(=O)NC(=O)CC9 |