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- 1. Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
- 2. Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
- 3. During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.
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