Temuterkib (LY3214996)

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Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.

Supplier	Selleck Chemicals
Product #	S8534
Sku #	S8534-10mM/1mL
Pricing	10mM/1mL, $327.00

Citations for this product:

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

Christel FA Ramirez, et al., bioRxiv - Cancer Biology 2023

Quote: ... Vx-11e and Temuterkib (S2673, S1078, S1555, S1460, S7709, S8534, Selleck Chemicals). Supernatants were collected to determine the secreted GM-CSF levels ...

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