Vorasidenib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-104042-10 mM * 1 mL |
| CAS # | 1644545-52-7 |
| Pricing | 10 mM * 1 mL, USD $137.0 |
| Synonyms | AG-881 |
| MWt | 414.74 |
| Formula | C₁₄H₁₃ClF₆N₆ |
| Biological Activity | Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K[1][2]. |
| Purity | 99.87% |