ONX-0914
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13207-10 mg |
| CAS # | 960374-59-8 |
| Pricing | 10 mg, USD $160.0 |
| Synonyms | PR-957 |
| MWt | 580.67 |
| Formula | C₃₁H₄₀N₄O₇ |
| Biological Activity | ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3]. |
| Purity | 99.70% |