Hypoxia Inducible Factor 1 Alpha (HIF1A) Antibody
Hypoxia Inducible Factor 1 Alpha (HIF1A) Antibody is a Mouse Monoclonal antibody for the detection of HIF1a.
Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256,.PMID: 7539918).
Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256,.PMID: 7539918).
| Supplier | Abbexa Ltd. |
|---|---|
| Product # | abx239939-100UG |
| Pricing | 100 µg USD $406.0 |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Host | Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| UniProt Primary AC | Q16665 |
| Dry Ice | No |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |