Fz7-21
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-P1454 |
| CAS # | 2247635-23-8 |
| Pricing | inquire |
| Biological Activity | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1]. |
| Synonyms | Ac-LPSDDLEFWCHVMY-NH2 |
| MWt | 1796.05 |
| Formula | C₈₃H₁₁₄N₁₈O₂₃S₂ |