Mouse Anti-DENV E Recombinant Antibody (clone 2H12)
2H12 binds to the highly conserved AB loop of domain III of the envelope protein that is poorly accessible in the mature virion. 2H12 neutralization varied between dengue serotypes and strains; in particular, dengue serotype 2 was not neutralized. Because the 2H12-binding epitope was conserved, this variation in neutralization highlights differences between dengue serotypes and suggests that significant conformational changes in the virus must take place for Ab binding. Surprisingly, 2H12 facilitated little or no enhancement of infection.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-S0024-YC |
| Pricing | Inquiry |
| Host | Mouse |
| Target | DENV E |
| Species Reactivity | DENV |
| Type | Mouse IgG |
| Applications | ELISA, Neut, FuncS |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |