Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); Fab Fragment
The YTS156.7 mAb inhibits this interaction and blocks T cell activation. To elucidate the molecular basis for this inhibition, the crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab at 2.7 A resolution. The YTS156.7 epitope on CD8beta was identified and implies that residues in the CDR1 and CDR2-equivalent loops of CD8beta are occluded upon binding to class I pMHC.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-S0182-YC-F(E) |
| Pricing | Inquiry |
| Host | Rat |
| Target | Cd8b1 |
| Species Reactivity | Mouse |
| Type | Rat Fab |
| Applications | Neut |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |