SKI-178
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12892-100 mg |
| CAS # | 1259484-97-3 |
| Pricing | 100 mg, USD $600.0 |
| Biological Activity | SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. SKI-178 is cytotoxic at IC50 concentrations ranging from 1.8 to 0.1 μM in both drug sensitive and multi-drug resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines[1][2]. |
| Purity | 98.05% |
| MWt | 394.42 |
| Formula | C₂₁H₂₂N₄O₄ |