Picropodophyllin (PPP)
Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7668 |
| Sku # | S7668-10mM/1mL |
| Pricing | 10mM/1mL, $127.00 |
Citations for this product:
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bioRxiv - Developmental Biology 2023Quote: ... 28-day-old C57/B6J mice received intraperitoneal injections of either the IGF-1 receptor tyrosine kinase inhibitor picropodophyllin (PPP, 20 μg/g body weight; SLK-S7668, Selleck Chemicals) or vehicle alone (dimethyl sulfoxide [D8418 ...