Cyclopamine, Free Base (11-Deoxyjervine, CAS 4449-51-8), 99%

LC Laboratories' Product Number C-8700 - Cyclopamine, Free Base (11-Deoxyjervine), 99% - for research use only. Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle. Induces chick embryo malformations associated with the interruption of Sonic hedgehog (Shh)-mediated dorsoventral patterning. Displays anti-tumor properties. It has been shown to induce apoptosis in both colorectal adenoma- and carcinoma-derived cell lines and in skin basal cell carcinomas. Pregnant cattle, goats, or sheep who graze on the corn lily plant (Veratrum californicum) at the 14th day of gestation can give birth to deformed offspring with a characteristic single eye in the middle of the forehead.

• Supplier: LC Laboratories
• Product #: C-8700
• Sku #: C-8700_25mg