A-366

Supplier MedChemExpress
Product # HY-12583-10 mM * 1 mL
CAS # 1527503-11-2
Pricing 10 mM * 1 mL, USD $86.0
Biological Activity A-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families[1][2][3][4].
Purity ≥98.0%
MWt 329.44
Formula C₁₉H₂₇N₃O₂
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