Ruxolitinib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-50856-1 g |
| CAS # | 941678-49-5 |
| Pricing | 1 g, USD $792.0 |
| Synonyms | INCB18424 |
| MWt | 306.37 |
| Formula | C₁₇H₁₈N₆ |
| Biological Activity | Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3]. |
| Purity | 99.99% |