Mouse Anti-NTRK2 Recombinant Antibody (clone 1G11)
Provided are TrkB binding agonists, wherein the agonist potentiates BDNF-induced and/or NT-4-induced agonism of TrkB. And such agonists can used in the treatment of neurological disorders and other disorders. 1G11 binds to and activates rodent (murine, rat), cynomolgus, and human TrkB receptors. 5D11 also activate rat, mouse and human TrkB receptors. Interestingly, 3A3 only activate the human TrkB receptors but not the rodent TrkB receptors. The species cross-reactivity was tested using either recombinantly expressed TrkB receptors in heterologous cell line or primary cells derived from corresponding species or human iPSC derived cells.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-N0197-YC |
| Pricing | Inquiry |
| Host | Mouse |
| Target | NTRK2 |
| Species Reactivity | Human, Cynomolgus, Mouse, Rat |
| Type | Mouse IgG |
| Applications | FuncS, WB |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |