Propylene Glycol Alginate
Propylene glycol alginate occurs as a white to yellowish colored, practically odorless and tasteless, fibrous or granular powder.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0547 |
| Pricing | , Inquire for price |
| product1 | Suspending Agents |
| Applications | / |
| Safety | Propylene glycol alginate is used in oral and topical pharmaceutical formulations, cosmetics, and food products. It is generally regarded as a nontoxic and nonirritant material, although excessive oral consumption may be harmful. A study in five healthy male volunteers fed a daily intake of 175 mg/kg body-weight of propylene glycol alginate for 7 days, followed by a daily intake of 200 mg/kg body-weight of propylene glycol alginate for a further 16 days, showed no significant adverse effects. Inhalation of alginate dust may be irritant and has been associated with industrially related asthma in workers involved in alginate production. However, it appears that the cases of asthma were linked to exposure to seaweed dust rather than pure alginate dust. LD50 (hamster, oral): 7.0 g/kg LD50 (mouse, oral): 7.8 g/kg LD50 (rabbit, oral): 7.6 g/kg LD50 (rat, oral): 7.2 g/kg |
| Synonyms | Alginic acid, propylene glycol ester; E405; hydroxypropyl alginate; Kelcoloid; Kimiloid; Manucol Ester; Profoam; Pronova; propane1, 2-diol alginate; Protanal; TIC Pretested |
| CAS Number | 9005-37-2 |
| Category | Emulsifying Agents; foam Stabilizer; Stabilizing Agents; Suspending Agents; Viscosity Increasing Agents |
| UNII | 26CD3J2R0C |
| Chemical Name | Propylene glycol alginate |
| Grade | Pharmceutical Excipients |
| Administration route | Oral |
| Dosage Form | Oral preparations |
| Stability and Storage Conditions | Propylene glycol alginate is a stable material, although it will gradually become less soluble if stored at elevated temperatures for extended periods. Propylene glycol alginate solutions are most stable at pH 3-6. In alkaline solutions, propylene glycol alginate is rapidly saponified.Alginate solutions are susceptible to microbial spoilage and should be sterilized or preserved with an antimicrobial preservative.However, sterilization processes may adversely affect the viscosity of propylene glycol alginate solutions. The bulk material should be stored in an airtight container in a cool, dry place. |
| Source and Preparation | Alginic acid, extracted from brown seaweed, is reacted with propylene oxide to form propylene glycol alginate. Various grades may be obtained that differ in composition according to the degree of esterification and the percentage of free and neutralized carboxyl groups present in the molecule; complete esterification of alginic acid is impractical. |