JNJ-61432059
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-111751-100 mg |
| CAS # | 2035814-50-5 |
| Pricing | 100 mg, USD $2680.0 |
| Biological Activity | JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1]. |
| Purity | 99.05% |
| MWt | 443.47 |
| Formula | C₂₅H₂₂FN₅O₂ |