Poziotinib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15730-10 mM * 1 mL |
| CAS # | 1092364-38-9 |
| Pricing | 10 mM * 1 mL, USD $106.0 |
| Synonyms | HM781-36B; NOV120101 |
| MWt | 491.34 |
| Formula | C₂₃H₂₁Cl₂FN₄O₃ |
| Biological Activity | Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity[1][2]. |
| Purity | 99.97% |