Rottlerin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18980-25 mg |
| CAS # | 82-08-6 |
| Pricing | 25 mg, USD $130.0 |
| Biological Activity | Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5]. |
| Synonyms | Mallotoxin; NSC 56346; NSC 94525 |
| MWt | 516.54 |
| Formula | C₃₀H₂₈O₈ |