HK2 (Hexokinase II) (Center) Antibody
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Althoμgh found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
| Supplier | Creative Biogene |
|---|---|
| Product # | PBCA1018 |
| Pricing | Inquiry |
| Isotype | Rabbit IgG |
| Research Area | Antibody |
| Antibody Target | HK2 (Hexokinase II) |
| Antibody Type | Polyclonal |
| Application | ELISA, WB, IHC |
| Formulation | 0.25 mg/ml of antibody in PBS with 0.09% (W/V) sodium azide |
| Appearance | Liquid |
| Host | Rabbit |
| Species Reactivity | Human |
| Usage Statement | Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses. |