R-130823
R-130823 is a highly selective inhibitor against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823, with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively.
| Supplier | BOC Sciences |
|---|---|
| Product # | 321344-32-5 |
| Pricing | Inquire |
| Cas | 321344-32-5 |
| Molecular Weight | 423.53 |
| Molecular Formula | C28H26FN3 |
| Canonical SMILES | C1CN(CC=C1C2=CNC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)CCC5=CC=CC=C5 |