UNC-2025
UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
| Supplier | BOC Sciences |
|---|---|
| Product # | B2693-462616 |
| Pricing | Inquire |
| Cas | 1429881-91-3 |
| Molecular Weight | 476.66 |
| Molecular Formula | C28H40N6O |
| Canonical SMILES | OC1CCC(N2C=C(C=3C=CC(=CC3)CN4CCN(C)CC4)C=5C=NC(=NC52)NCCCC)CC1 |