Dexmecamylamine HCl
Dexmecamylamine, also known as TC-5214 and NIH-11008, is a nicotinic channel modulator with antidepressant activity. TC-5214 demonstrated positive effects in a number of animal models of depression and anxiety. TC-5214 was active in the forced swim test in rats (minimum effective dose (MED)=3 mg/kg i.p.), a classical depression model. It was also active in the behavioral despair test in mice (0.1-3.0 mg/kg i.p.), another model of depression.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD194 |
| CAS # | 107596-30-5 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | TC-5214; TC 5214; TC5214; NIH-11008; NIH 11008; NIH11008; Dexmecamylamine; Dexmecamylamine HCl |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C11H22ClN |
| Exact Mass | 167.1674 |
| Molecular Weight | 203.754 |
| Elemental Analysis | C, 64.84; H, 10.88; Cl, 17.40; N, 6.87 |
| IUPAC/Chemical Name | (1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride |
| InChi Key | PKVZBNCYEICAQP-GSTSRXQZSA-N |
| InChi Code | InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1 |
| SMILES Code | CC1(C)[C@](NC)(C)[C@]2([H])CC[C@@]1([H])C2.[H]Cl |
| Appearance | White to off-white solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |