PROTAC Mcl1 degrader-1
PROTAC Mcl1 degrader-1 is a proteolysis targeting chimera (PROTAC) based on Cereblon ligand that is a potent and selective inhibitor of McL-1 (Bcl-2 family member), with an IC50 of 0.78 μM. It induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2163793-38-0 |
| Pricing | Inquire |
| Cas | 2163793-38-0 |
| Molecular Weight | 909.84 |
| Molecular Formula | C45H45BrN6O8S |
| Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O |