JNJ-18038683 citrate
JNJ-18038683 is a 5-HT7 receptor antagonist which has been shown to be effective in models of depression and to increase the latency to rapid eye movement (REM) sleep and decrease REM duration. JNJ-18038683 enhanced serotonin transmission, antidepressant-like behavior, and REM sleep suppression induced by citalopram in rodents.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD894 |
| CAS # | 851376-05-1 (citrate) |
| Pricing | Customizable size, Inquiry |
| Synonym | JNJ-18038683 citrate; JNJ-18038683; JNJ 18038683; JNJ18038683. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H28ClN3O7 |
| Molecular Weight | 529.974 |
| Elemental Analysis | C, 58.92; H, 5.33; Cl, 6.69; N, 7.93; O, 21.13 |
| IUPAC/Chemical Name | 3-(4-chlorophenyl)-1-(phenylmethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[5,4-d]azepine citrate |
| InChi Key | DIQZMBPDLFAJLK-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C20H20ClN3.C6H8O7/c21-17-8-6-16(7-9-17)20-18-10-12-22-13-11-19(18)24(23-20)14-15-4-2-1-3-5-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-9,22H,10-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| SMILES Code | ClC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2CCNCC4)C=C1.OC(C(O)=O)(CC(O)=O)CC(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |