Afatinib Dimaleate
Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7810 |
| Sku # | S7810-10mg |
| Pricing | 10mg, $97.00 |
Citations for this product:
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bioRxiv - Neuroscience 2022Quote: ... The epidermal growth factor receptor (EGFR) irreversible inhibitor afatinib dimaleate (Ref. S7810, Selleck Chemicals LLC, Houston, TX, USA) was diluted with saline to a concentration of 2 mg/Kg and injected intrahippocampally immediately prior to KA delivery following the same steps as for the KA injection ...